I've been having this problem lately where upon loading WoW, everything is fine, but as I play, the sound gets choppy and staticy to the point where I can't listen to it anymore. I thought it might be a sound driver issue but windows says everything is up to date, plus things like Youtube and other streaming audio/video works just fine. I just recently upgraded to Windows 7 Home 64, in part because of this problem (thinking it was a Vista 64 issue, plus I wanted to anyway), but after running extensive Windows Updates after the upgrade and clean WoW installation it's still choppy (although I did copy over my Interface and WTF folders to keep my addon preferences). Additionally, it usually starts out with no issue whatsoever, but as I play longer, it gets worse and worse. This happens on multiple characters. It requires a reboot to fix, at which point it's fine again and only a matter of time before it gets bad again. I've also gone through three sets of headphones and used three different USB jacks for them thinking that might be the issue, but it didn't help.

I'm not exactly a computer "geek" but I do know my way around, so if you let me know how to find the system description listing whatever it is that everyone else copy/pastes in their posts, I'll be happy to provide that for you.

Can you post your sesound.log file from your World of Warcraft\Logs folder? It might have a clue that we can use. If you don't have a log file, you can try turning off the game's Use Hardware option, the Reverb option and try lowering the number of sound channels in the Sound options to see if it helps